Postdoctoral research position 

EPSRC-funded postdoctoral position available (2018): development of Raman spectroscopy for in-vivo assessment of tumour margins during cancer surgery. 


PhD studentships

Fully-funded PhD studentship available starting in September 2018: The projects will explore the use of Raman micro-spectroscopy for imaging and diagnosis of cells and tissues.

For further details and information on how to apply, please contact Ioan Notingher

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Optics in Clinical Practice IV, IOP Optical Group workshop

March 22, 2018

 Organised by the Optical Group of the Institute of Physics, a one-day workshop discussing optics developments in clinical practice. The meeting is organised around 7 invited talks by clinicians and academics, covering a broad range of optical techniques. 

Full programme 


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EPSRC Established Career Fellowship

July 2014

The fellowship will explore the use of Raman spectroscopy and multimodal spectra imaging for intra-operative assessment of tumour margins, one of the key challenges in cancer surgery. The research will focus on spatial light modulators, micro-scale optical elements and selective sampling Raman spectroscopy to increase the speed of tumour diagnosis towards real-time. In the same time, the potential of these technologies for diagnosis of breast and lung cancers will also be explored.

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Towards real-time diagnosis of basal cell carcinoma during Mohs micrographic surgery

April 2014

The Confidence in Concept award will investigate the feasability of a new technique based on Raman microscopy aimed at increasing the speed of multimodal spectral histopathology for intra-operative diagnosis of tumours. If succesful, this new technique will open the door for real-time diagnosis, without requiring tissue preparation (sectioning, fixation, staining).  

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Fast diagnosis of basal cell carcinoma during Mohs micrographic surgery

February 2014


The aim of this translational i4i grant is to develop a first instrument for diagnosis of basal cell carcinoma (BCC) during Mohs micrographic surgery. The optimised instrument is based on the new multimodal spectral histopathology technique developed by the team (PNAS 2013 110, 15189-15194). This first generation prototype instrument will allow Mohs surgeons to diagnose BCC within 5 minutes, for each tissue layer removed during surgery. 

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New project grant to increase the speed of skin cancer diagnosis by Raman microscopy

July 2013

Basal cell carcinoma (BCC) is the commonest cancer in humans with 60,000 new patients being diagnosed each year in the UK. Mohs micrographic surgery (MMS) is the most effective treatment method, but requires lengthy and costly tissue preparation procedures for intra-operative diagnosis. This project  will integrate the latest technological developments to design and build an instrument to demonstrate objective diagnosis of BCC in thick tissue layers removed during Mohs micrographic surgery in only 5 minutes. With such short diagnosis times and without requiring any tissue preparation, several layers of tissue can be excised and evaluated within a single intervention. These potential changes in surgery practice will improve the MMS efficiency (reduce costs and surgery time) and patient care, allowing all BCC patients to benefit from the best treatment available.

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Speeding up cancer diagnosis during surgery

September 2013

Tissue-conserving cancer surgery is a highly skilled procedure which involves time-consuming tissue preparation to detect the margins of cancerous tissue. The goal is to remove as much of the tumour as possible while sparing healthy tissue. 
With funding from the National Institute for Health Research (NIHR), our group has developed a highly accurate prototype technique which can produce a detailed ‘spectroscopic fingerprint’ of each tissue layer removed during surgery.

PhD and MRes studentships

We welcome applications for PhD and MRes studentships for projects in biophotonics and biophysics. The main areas of research are:

PhD Raman tip enhanced

Nanoscale optics and spectroscopy

  • Tip-enhanced Raman microscopy
  • Characterisation of bio nanomaterials by intergrated atomic force microscopy and polarised Raman microscopy

Raman cell imaging PhD Nottgham

Live cell imaging: Raman microscopy for label-free molecular imaging of live cells

  • Development of selective scanning technique for fast molecular imaging of cells by Raman microscopy
  • Development of techniques for increasing chemical specificity in Raman microscopy of cells
  • Label-free imaging of cells with applications in tissue engineering, regenerative medicine, immunology and canecr research
  • Label-free Raman-activated cell sorting of stem cells 
PhD Nottingham Raman cancer

Cancer diagnosis: development of Raman spectroscopy histopathology techniques

  • Integration of tissue-autofluorescence imaging and Raman microscopy for fast diagnosis of tissues
  • Multiplex multimodal spectral imaging
  • Development of hand-held probes for in-vivo diagnosis of tumours by multimodal spectral imaging
  • Development of Raman spectroscopy diagnosis of skin, breast, lung and brain tumours

Oxford-Nottingham Centre for Doctoral Training in Biomedical Imaging

(co-funded by EPSRC and MRC). 

Applications from UK students with a physics, engineering, chemistry or mathematics/computer science background, who must eventually work on projects that fall within the EPSRC/MRC scope, are invited.

For informal discussion about projects, please contact Dr Ioan Notingher:


For formal applications, please use the University of Nottingham posgraduate online application at